Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1361
Gene Symbol: CPB2
CPB2
0.010 AlteredExpression disease BEFREE • Increased activity of thrombin activatable fibrinolysis inhibitor (TAFI) may contribute to impaired fibrinolysis in patients with rheumatoid arthritis. 31209709 2019
Entrez Id: 4179
Gene Symbol: CD46
CD46
0.040 Biomarker disease BEFREE • In this study, we evaluated the diagnostic accuracy of US and MRI for bone erosion in RA patients, neither MRI nor US showed perfect diagnostic test accuracy.• 1.5-T Signa system and the LOGIQ units both from General Electric© are the machine types of MRI and US with the greatest performance, respectively.• The 2nd MCP joint is the scanning position recommended during US test.• Different reference standards will greatly influence the judgment of the results. 31713730 2019
Entrez Id: 822
Gene Symbol: CAPG
CAPG
0.020 Biomarker disease BEFREE • In this study, we evaluated the diagnostic accuracy of US and MRI for bone erosion in RA patients, neither MRI nor US showed perfect diagnostic test accuracy.• 1.5-T Signa system and the LOGIQ units both from General Electric© are the machine types of MRI and US with the greatest performance, respectively.• The 2nd MCP joint is the scanning position recommended during US test.• Different reference standards will greatly influence the judgment of the results. 31713730 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE • GAS5 and IL-8 were correlated in RA patients but not in healthy controls. 31372853 2019
Entrez Id: 11285
Gene Symbol: B4GALT7
B4GALT7
0.010 Biomarker disease BEFREE β1,4-Galactosyltransferase-I contributes to the inflammatory processes in synovial tissue of patients with rheumatoid arthritis. 20490888 2010
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 GeneticVariation disease LHGDN [The presence of dry eye syndrome and corneal complications in patients with rheumatoid arthritis and its association with -174 gene polymorphism for interleukin 6]. 18419107 2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease LHGDN [Role of TNF-alpha and cytokines in the physiopathology of rheumatoid arthritis. Therapeutic perspectives]. 14979058 2003
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.100 AlteredExpression disease LHGDN [B lymphocyte stimulator (BLyS) and monocytes: possible role in autoimmune diseases with a particular reference to rheumatoid arthritis]. 15470519 2004
Entrez Id: 56603
Gene Symbol: CYP26B1
CYP26B1
0.010 AlteredExpression disease BEFREE Zebrafish mutants with increased retinoic acid (RA) signaling due to the loss of the RA-inactivating enzyme Cyp26b1 develop a hyper-mineralized spine with gradually fusing vertebral body precursors (centra). 29650589 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.350 Biomarker disease CTD_human Yohimbine hydrochloride ameliorates collagen type-II-induced arthritis targeting oxidative stress and inflammatory cytokines in Wistar rats. 27028940 2017
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
0.030 Biomarker disease BEFREE YAP promoted TGFβ-dependent SMAD3 nuclear localisation in RA FLS. 30808624 2019
Entrez Id: 4179
Gene Symbol: CD46
CD46
0.040 Biomarker disease BEFREE Wrist and MCP erosion scores were also associated with RA activity. 30160204 2018
Entrez Id: 822
Gene Symbol: CAPG
CAPG
0.020 Biomarker disease BEFREE Wrist and MCP erosion scores were also associated with RA activity. 30160204 2018
Entrez Id: 7357
Gene Symbol: UGCG
UGCG
0.010 AlteredExpression disease BEFREE Women with premenopausal onset of RA not previously treated with GCS had lower basal serum levels of adrenal androgens, that is, DHEA or DHEAS, both before and after onset of clinical disease, compared with controls. 10553979 1999
Entrez Id: 2729
Gene Symbol: GCLC
GCLC
0.010 AlteredExpression disease BEFREE Women with premenopausal onset of RA not previously treated with GCS had lower basal serum levels of adrenal androgens, that is, DHEA or DHEAS, both before and after onset of clinical disease, compared with controls. 10553979 1999
Entrez Id: 8838
Gene Symbol: CCN6
CCN6
0.020 AlteredExpression disease LHGDN Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis. 15517620 2004
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Within the CD4 T lymphocytes subset we found that the CD45RO- (naive) cells selectively in RA displayed higher levels of CD25 protein and of interferon-gamma mRNA expression when compared with the respective subset of all other investigated groups. 1347492 1992
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 AlteredExpression disease BEFREE Within the CD4 T lymphocytes subset we found that the CD45RO- (naive) cells selectively in RA displayed higher levels of CD25 protein and of interferon-gamma mRNA expression when compared with the respective subset of all other investigated groups. 1347492 1992
Entrez Id: 3669
Gene Symbol: ISG20
ISG20
0.200 AlteredExpression disease BEFREE Within the CD4 T lymphocytes subset we found that the CD45RO- (naive) cells selectively in RA displayed higher levels of CD25 protein and of interferon-gamma mRNA expression when compared with the respective subset of all other investigated groups. 1347492 1992
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 AlteredExpression disease BEFREE Within RA patients the plasma levels of IFNᵧ were lower in patients with low RA disease activity or remission. 28288327 2017
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 AlteredExpression disease BEFREE Within RA patients the plasma levels of IFNᵧ were lower in patients with low RA disease activity or remission. 28288327 2017
Entrez Id: 133
Gene Symbol: ADM
ADM
0.060 GeneticVariation disease BEFREE Within each of 100 families, one RA-affected patient and both parents underwent genotyping for polymorphisms of adrenomedullin, CRLR and RAMP-2, by PCR-restricted fragment-length polymorphism (RFLP) or Taqman 5' allelic discrimination assay. 19210874 2009
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 Biomarker disease BEFREE Within RA discordant twin pairs PTPN22(T) positive RA twins had a significantly lower amount than their co-twins (-16.3 mtDNA CN). 30327147 2019
Entrez Id: 338
Gene Symbol: APOB
APOB
0.030 GeneticVariation disease BEFREE Within RA, the E2 allele was associated with the lowest and E4 allele with the highest levels of total cholesterol (p = 0.007), low-density lipoproteins (p = 0.004), and apolipoprotein B (p = 0.009). 22174202 2012
Entrez Id: 213
Gene Symbol: ALB
ALB
0.100 GeneticVariation disease BEFREE With those variables, multiple stepwise forward regression analysis was conducted and revealed that CCr, DAS28-ESR and CRP are the statistically significant explanatory variables on oxidized-albumin (%) among well-controlled RA patients. 27778459 2018